Conditioning is hormesis training of mitochondria that resets apoptosis thresholds, ultimately enhancing cellular energy and improving mitochondrial function. When a mitochondrion is sufficiently oxidized and can no longer maintain adequate voltage across the IMM, it releases cytochrome c oxidase (ETC complex 4) into the cell cytoplasm, leading to apoptosis, or programmed cell death. For cells capable of recycling entire cells from stem cells, such as red blood cells, this system is excellent for recycling into new, young cells. However, some cells, like neurons and retinal ganglion cells, are lifelong and excessive apoptosis can lead to diseases such as dementia and glaucoma. By resetting apoptosis thresholds in target cells, conditioning can maintain cellular function despite the functional decline associated with aging, effectively buying time for processes like mitophagy and biogenesis to slow or potentially reverse aging. There are known repurposed medications and light therapies that represent just a few of the potential conditioning strategies for wellness enhancement.